A new study co-authored by Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology and Division of Reproductive Sciences Director Manish Patankar, PhD was published in the journal Cancers!
“Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers” outlines the Barroilhet and Patankar Labs’ research of the FDA-approved antimalarial drug atovaquone and its potential impact on gynecologic cancer:
“Our laboratory studied the anti-cancer properties of atovaquone in gynecologic cancers. We found that atovaquone slowed ovarian cancer growth in both cell lines and mouse models. Additional anti-cancer effects were seen, such as the reduced proliferation of cancer stem cells and spheroids implanted in mice. Atovaquone inhibited oxygen consumption and ATP production. Metabolic studies showed that atovaquone shifted glycolysis, electronic transport and the citric acid cycle. Our studies provided the mechanistic understanding and preclinical data to support the further investigation of atovaquone’s potential as a cancer therapy for gynecologic cancers.”
Read the whole study here. Congratulations to the Barroilhet and Patankar research groups on this exciting development!
This fall, the UW Carbone Cancer Center will raise awareness and funds for cancer research with the Badger Challenge (formerly The Ride). The walking, running, and biking event on September 25, 2022 supports promising new cancer research and treatment opportunities at the University of Wisconsin. You can join the UW Ob-Gyn team and run, walk, or bike along with us!
Learn more about how to donate to support the UW Ob-Gyn team or join in on the activities on September 25 here.
Badger Challenge is a signature Wisconsin walking, running, and biking event which energizes the community around the mission of raising funds for cancer research and patient treatment at the University of Wisconsin-Madison and the UW Carbone Cancer Center. The UW research environment brings together scientists and clinicians from a wide variety of disciplines to help solve complex problems affecting patient care, and Badger Challenge accelerates the rate at which collaboration and discovery occurs.
Since the May 2 leak of a draft U.S. Supreme Court memo that suggests the court’s intention to overturn Roe v. Wade later this summer, researchers and scholars have shared insights on the current landscape of abortion access in the country, and potential implications for the coming Supreme Court decision.
UW Collaborative for Reproductive Equity and UW Ob-Gyn Division of Reproductive and Population Health Director Jenny Higgins, PhD, MPH has shared expertise on Wisconsin Public Radio and CBS-58 in recent weeks:
State data: About 6,400 abortions were performed in Wisconsin in 2020 – Wisconsin Public Radio
In this article, Higgins discussed some state-level restrictions that make abortion access challenging for people in Wisconsin:
“Higgins also cited the state's 24-hour waiting period and requirements for medication abortions as barriers to the procedure, and noted there are only a few abortion clinics in the state, which means many patients have to travel several hours to undergo a surgical abortion.
"There are a variety of restrictions that work synergistically to make it difficult for people to both travel to and afford services," she said.”
Where Wisconsinites stand on abortion access – The Morning Show, Wisconsin Public Radio
Higgins joined Wisconsin Public Radio’s The Morning Show on May 11, 2022 to talk about research into public opinion on abortion access, health outcomes that could be affected by abortion restrictions, and more. You can listen to the whole interview here – her appearance begins at 5:06.
In two appearances on CBS-58 in Milwaukee, Higgins provided statistics and background about abortion trends in Wisconsin, and talked about how people in Wisconsin may find abortion care if Roe v. Wade is overturned:
A look at abortion by the numbers in Wisconsin, US – CBS-58
Some worry women will seek unsafe abortion options if current access becomes limited – CBS-58
Are you looking for community or opportunities for fun activities outside of work? Take a look at the survey (link below) and let us know if you'd be interested in being part of a group for any of the activities! The survey includes suggested activities in categories like dining, arts and entertainment, outdoor sports, crafts, and more. We welcome your additions for activity groups you’d like to see, too!
Please follow this link to the survey!
The Wellness Committee will connect anyone who expresses interest in the same activities, and you can run with the coordination from there!
Faculty and fellows in the UW Ob-Gyn Division of Female Pelvic Medicine and Reconstructive Surgery will bring research and presentations to the American Urogynecologic Society and International Urogynecological Association 2022 Annual Scientific Meeting in Austin, TX, June 15-16! Read more about some of the exciting developments they will share at the meeting:
Oral abstract: A Pilot Study of Home-Based Pelvic Muscle Training for Vaginal Symptoms Among Survivors of Breast Cancer (Jon Pennycuff, MD, MSPH, presenter)
Oral abstract: The Variation of Chargemaster Price Listings for Urogynecologic Procedures (Dobie Giles, MD, co-author)
Oral abstract: BP Connect: Referring Urogynecology Patients with High Blood Pressure for Primary Care Follow-up (Heidi Brown, MD, MAS, presenter; Makeba Williams, MD, co-author)
Oral abstract: Urinary Incontinence Prevalence and Care-seeking in a Predominantly Black / African-American Sample of Community-dwelling Women (Kristina Warner, MD, presenter)
Abstract: A Comparison of Vaginal pH using Prasterone, Estradiol Cream or Non-hormonal Vaginal Moisturizer for Genitourinary Syndrome of Menopause (VpHresh) (Jon Pennycuff, MD, MSPH, co-author)
Abstract: Surgeon Counseling Regarding Return to Sexual Activity After Pelvic Reconstructive Surgery (Christine Heisler, MD, co-author)
While at the meeting, the FPMRS team will also compete in the AUGS/IUGA Foundations' Fun Walk/Run & Cornhole Tournament for Pelvic Floor Disorders. Learn more about how you can support the Wisconsin Honey Badgers in the cornhole tournament!
On Wednesday, May 4, members of the UW Ob-Gyn outreach team delivered a load of diapers purchased through our annual diaper drive to community partners at the River Food Pantry!
Our annual Diaper Drive supports families in the Madison area by collecting monetary donations to the department's Healthy Women Healthy Babies Fund. Using this fund enables the department to leverage university purchasing avenues to buy diapers at a steeply discounted rate and distribute them to local organizations that support families with infants and toddlers in our community.
Help kick off planning and fundraising for the Promise Walk for Preeclampsia with a brat fry on Saturday, June 4! The kick-off event is hosted by the Madison Promise Walk for Preeclampsia, and will feature special guest Eleni Tsigas, CEO of the Preeclampsia Foundation.
Join the brat fry at Lake Farm County Park at 11:00am – more details are available on Facebook.
The Promise Walk for Preeclampsia will take place on September 10, 2022. Learn more about how to join the walk and how to support the Staying Healthy After Childbirth team as they raise funds for preeclampsia research!
The American College of Obstetricians and Gynecologists held the Annual Clinical and Scientific Meeting in San Diego May 6-8, 2022. Faculty, fellows and residents in the UW Department of Ob-Gyn brought many exciting presentations and projects to the conference. Read more about some of their awesome accomplishments:
Division of Academic Specialists in Ob-Gyn Director Makeba Williams, MD gave the Morton and Diane Stenchever Lecture “The Women’s Health Initiative: Controversy, Confusion, Consensus” at the opening of the day on May 8:
“In 2022, is hormone therapy safe? Have we reached a point of consensus? The Women’s Health Initiative hormone therapy trial preliminary results were released summer 2002, completely altering the practice of prescribing hormone therapy to midlife and menopausal women. Controversy and confusion immediately ensued. Attend this thought-provoking session to better understand current recommendations, management strategies and treatment options for menopausal patients.”
Division of Gynecologic Oncology Director Stephen Rose, MD, presented “A Revised Markov Model Evaluating Oophorectomy at the Time of Hysterectomy for Benign Indication”, co-authored by Gynecologic Oncology Fellow Shannon Rush, MD, during a late-breaking abstracts session on May 8.
More posters and presentations:
Black Women With Low Numeracy Fare Worse in Diabetic Pregnancies - Jennifer Jacobson, MD; Amy Godecker, PhD; Jennifer Janik, MD; April Eddy, MS; Jacquelyn Adams, MD
Assessment of In-Hospital Pain Control After Childbirth and Its Correlation With Anxiety in the Postpartum Period – Clara Olson, BS; John Poehlmann, MD; Zachary Stowe, MD; Kathleen Antony, MD
Clinical Application of a Previously Validated Pregnancy-Specific Screening Tool for Sleep Apnea – Kathleen Antony, MD
Operationalizing Aspirin to Reduce Preeclampsia Risk and Related Morbidity and Mortality – Maya Gross, MD; Katherine Sampene, MD
Leveraging Quality Improvement to Promote Health Equity: Prenatal Aspirin Recommendations by Race - Maya Gross, MD; Katherine Sampene, MD
In the Eye of the Beholder: Perspectives of Fellowship Applicants on Virtual Interviews - Christine Heisler, MD
Cost-Effectiveness of Opportunistic Salpingectomy Following Vaginal Delivery for Ovarian Cancer Prevention – Matthew Wagar, MD; Makeba Williams, MD
Incredible work, all!
Please help us congratulate Assistant Professor Laura Birkeland, MS, CGC, who recently became the next program director of the UW SMPH Master of Genetic Counselor Studies! Birkeland will provide expert leadership, vision, and oversight to continue the growth and positive impact of this important health professions education program.
Laura joined the UW SMPH in 2006, and has been the assistant program director for the Master of Genetic Counselor Studies Program since 2014. Learn more about Laura’s new role here! Congratulations on this well-deserved honor!