Huge congratulations to Dave Abbott, PhD, of the UW Ob-Gyn Division of Reproductive Sciences! Abbott is senior author on an invited paper in the International Journal of Molecular Sciences’ Special Issue on PCOS.
“Experimentally Induced Hyperinsulinemia Fails to Induce Polycystic Ovary Syndrome-like Traits in Female Rhesus Macaques” demonstrates that while compensatory elevations of endogenous insulin levels due to insulin resistance are associated with PCOS in both women and rhesus monkeys, experimentally controlled elevations of human exogenous insulin in circulation do not cause PCOS in control monkeys and do not worsen PCOS signs and symptoms.
It is commonly assumed that insulin resistance driven hyperinsulinemia is a cause of PCOS in women, but this monkey experiments suggests that may not be the case. Thus while there are associations, they alone do not cause PCOS.
Read the whole article here!