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Congratulations to the Stanic Lab, along with colleagues
from the Division of Maternal-Fetal Medicine and the Ong Lab, who were just
published in the journal Frontiers in Immunology!
“Transcriptional
and Functional Programming of Decidual Innate Lymphoid Cells” is a study
spearheaded by lead author Jessica Vazquez, PhD, a post-doctoral fellow in the
Stanic Lab, and was a joint effort with Deborah Chasman, PhD (Irene Ong lab)
and Chanel Tyler, MD (MFM).
It focuses on
the discovery of novel innate immune cells in the decidua in human pregnancy at
term identified by Vazquez and colleagues. Detailed analysis – using a
multitude of advanced single cell technologies over three years of laboratory
work – demonstrates functional properties associated with pregnancy success
(secretion of cytokines/factors associated with angiogenesis, vascular
remodeling).
Analysis, in collaboration with the Ong Lab, also reveals
continuity of these cell types at term pregnancy with those identified in first
trimester decidua by a large sequencing consortium in England. This work is an
example of collaborative studies between basic/translational scientists,
clinicians and computational scientists in our department that drive pregnancy
research forward.
You can read
the whole manuscript here. Incredible work by everyone involved!
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