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Knowledge Portal > News > Posts > Stanic published in Frontiers in Immunology; receives RSDP grant
October 10
Stanic published in Frontiers in Immunology; receives RSDP grant

Lots of great news from Aleks Stanic, MD, PhD, of the UW Ob-Gyn Divisions of Reproductive Endocrinology and Infertility and Reproductive Sciences!

Stanic’s article “Decidual-Placental Immune Landscape during Syngeneic Murine Pregnancy” was recently published in the journal Frontiers in Immunology. The study examined the roles of immune cells in gestational tissue dynamics. Read the whole study here.

Stanic also received a Burroughs Wellcome Fund (BWF)-supported RSDP seed grant for his research project “Distribution and function of Innate-like T lymphocytes at the maternal-fetal interface.” The $25,000 pilot grant will fund his research through June 2019. Research abstract:

Disordered immune response at the maternal fetal interface and/or pro-inflammatory bacterial colonization is thought to be a major underlying cause of Preterm birth (PTB), the leading cause of maternal/fetal morbidity. Attempts to treat with antibiotics and an extensive search for causative organism(s) has not yet resulted in validated therapeutic targets have emerged. Dr. Stanic’s primary RSDP-supported project, while focused on Innate Lymphoid cells, unexpectedly revealed expansion of effector-phenotype T cells, resembling mucosal-associated invariant T (MAIT) cells. MAIT cells play key roles in immunity and exhibit a complex interaction with the microbiota, protecting against bacterial infections, but also requiring a host microbiome for fetal and adult development. Research in Stanic lab suggests that MAIT cells may be pathologically relevant at the decidual : placental (maternal-fetal) interface.

RSDP Seed support will provide pilot funds to establish firm preliminary evidence for MAIT relevance in human decidual physiology.”

Congratulations, Dr. Stanic! 


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